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ey0018.9-5 | Surveillance strategies of endocrine complications | ESPEYB18

9.5. Beyond premature ovarian Insufficiency: staging reproductive aging in adolescent and young adult cancer survivors.

ACO Medica , BW Whitcomb , K Shliakhsitsava , AC Dietz , K Pinson , C Lam , SAD Romero , P Sluss , MD Sammel , HI Su

J Clin Endocrinol Metab. 2021;106: e1002e1013. https://pubmed.ncbi.nlm.nih.gov/33141175/This cross-sectional study applied a commonly used system to classify reproductive aging (Stages of Reproductive Aging Workshop +10 or STRAW +10) to 338 adolescents and young adult (AYA) cancer survivors (1). The study aimed to evaluate if STRAW +10 correctly identifies premature ovaria...

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ey0016.4-9 | New Perspectives | ESPEYB16

4.9. Low IGF-I bioavailability impairs growth and glucose metabolism in a mouse model of human PAPPA2 p.Ala1033Val mutation

M Fujimoto , M Andrew , L Liao , D Zhang , G Yildirim , P Sluss , B Kalra , A Kumar , S Yakar , V Hwa , A Dauber

To read the full abstract: Endocrinology. 2019;160:13631376.Pregnancy-associated plasma protein A2 (PAPP-A2) is a metalloproteinase which, by cleaving IGFBP-3 and IGFBP-5, releases free IGF-I from the ternary complexes and regulates its bioavailability. PAPPA2 gene mutations (p.D643fs25* and p.Ala1033Val) have recently been described in various members of two unrelated fam...

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ESPE Yearbook of Paediatric Endocrinology

9.5. Beyond premature ovarian Insufficiency: staging reproductive aging in adolescent and young adult cancer survivors.

4.9. Low IGF-I bioavailability impairs growth and glucose metabolism in a mouse model of human PAPPA2 p.Ala1033Val mutation

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